Author/Authors :
J. W. Clitherow، نويسنده , , P. Beswick، نويسنده , , W. J. Irving، نويسنده , , D. I. C. Scopes، نويسنده , , J. C. Barnes، نويسنده , , Phillip J. Clapham، نويسنده , , J. D. Brown، نويسنده , , D. J. Evans، نويسنده , , A. G. Hayes، نويسنده ,
Abstract :
Replacement of the isothiourea moiety of known histamine H3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H3 antagonist.
