Title of article
Modeling of solvent effects in the activation of the lipase from Rhizomucor miehei
Author/Authors
Fabio Benedetti، نويسنده , , Federico Berti، نويسنده , , Paolo Linda، نويسنده , , Stanislav Miertus، نويسنده , , Andrea Sabot، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
839
To page
844
Abstract
the effects of water and hydrophobic solvents on the stability of the open and closed forms of R. miehei lipase were evaluated with different solvent models. Desolvation of arginine 86 at the water-lipid interface plays a key role in the activation process, while the contribution from hydrophobic stabilization of the open form is less important.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788012
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