Author/Authors :
Sang-sup Jew، نويسنده , , Hee-Jin Kim، نويسنده , , Myoung Goo Kim، نويسنده , , Eun-Young Roh، نويسنده , , Youn-sang Cho، نويسنده , , Joon-Kyum Kim، نويسنده , , Kyung-Hoe Cha، نويسنده , , Kang-Keun Lee، نويسنده , , Hyun-Jung Han، نويسنده , , Jae-Young Choi، نويسنده , , Heesoon Lee، نويسنده ,
Abstract :
Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6c exhibited significant antitumor activity at wider range of doses as compared with camptothecin (T/C 243 % at 70mg/kg; T/C> 150% at 8.75–140mg/kg).
