Title of article
Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues
Author/Authors
Sang-sup Jew، نويسنده , , Hee-Jin Kim، نويسنده , , Myoung Goo Kim، نويسنده , , Eun-Young Roh، نويسنده , , Youn-sang Cho، نويسنده , , Joon-Kyum Kim، نويسنده , , Kyung-Hoe Cha، نويسنده , , Kang-Keun Lee، نويسنده , , Hyun-Jung Han، نويسنده , , Jae-Young Choi، نويسنده , , Heesoon Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
845
To page
848
Abstract
Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6c exhibited significant antitumor activity at wider range of doses as compared with camptothecin (T/C 243 % at 70mg/kg; T/C> 150% at 8.75–140mg/kg).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788013
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