Author/Authors :
A. Varvaresou، نويسنده , , A. Tsotinis، نويسنده , , Th. Siatra-Papastaikoudi، نويسنده , , A. Papadaki-Valiraki، نويسنده , , D. E. Thurston، نويسنده , , T. C. Jenkins، نويسنده , , L. R. Kelland، نويسنده ,
Abstract :
A new class of DNA-binding ligands (10a-f) has been synthesized and examined for DNA-binding affinity using thermal denaturation and for in vitro cytotoxicity in a number of cell lines. All the compounds were found to possess significant DNA-binding affinity which correlates with in vitro cytotoxicity across eight cell lines.
