Oxiranes with quinoline substitution : Stereoselective synthesis and antiviral activity

A series of new quinoline substituted oxiranes were synthesised by the reaction of 2-N-(chloroacetyl)-1-(4′-methyl -2′- quinolinyl) hydrazide and aromatic aldehydes. These compounds were tested against encephalomyocarditis virus (EMCV) and only two compounds exhibited protection against the virus.