Author/Authors :
Rosario Gonz?lez-Mu?iz، نويسنده , , M José Dom?nguez، نويسنده , , Mercedes Mart?n-Mart?nez، نويسنده , , Rosario Herranz، نويسنده , , M Teresa Garc?a-L?pez، نويسنده , , Ana Barber، نويسنده , , Santiago Ballaz، نويسنده , , Joaqu?n Del R?o، نويسنده ,
Abstract :
A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizidine bicyclic lactam as conformational constraint, is described. The 8-(Boc-tryptophyl)amino-2-benzyl derivatives behave as weak CCK-A or CCK-B receptor antagonists. The main factors for selectivity are the configuration at C-2 position of the 3-oxoindolizidine ring and at the Trp residue.
