Title of article
Synthesis and protein kinase C inhibitory activities of indane analogs of balanol
Author/Authors
Hong Hu، نويسنده , , Sean P. Hollinshead، نويسنده , , Steven E. Hall، نويسنده , , Kiyomi Kalter، نويسنده , , Lawrence M. Ballas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
973
To page
978
Abstract
Regio- and stereoisomeric indane analogs (4–6) of balanol (−)-1, a potent protein kinase C (PKC) inhibitor, were synthesized in which the perhydroazepine of balanol was replaced by an indane nucleus. Analog (−)-4 and its racemic regioisomer 6 were found to have highly potent PKC inhibitory activities. In addition, compound (−)-4 displayed excellent kinase selectivity for PKC over PKA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788041
Link To Document