Author/Authors :
Adam McCluskey، نويسنده , , Cherie Taylor، نويسنده , , Ronald J. Quinn، نويسنده , , Masami Suganuma، نويسنده , , Hirota Fujiki، نويسنده ,
Abstract :
The syntheses of several cantharidin analogues and their biochemical effects on protein phosphatase 2A are described. Comparison of the PP2A inhibition of these cantharidin analogues has shown that the 7-oxo moiety and the anhydride system contribute to the biochemical activity. The diacid forms of several anhydrides showed reduced inhibition of PP2A.
