Author/Authors :
Jean-Marc de Muys، نويسنده , , Rabindra Rej، نويسنده , , Dieu Nguyen، نويسنده , , Brian Go، نويسنده , , Samuel Fortin، نويسنده , , Jean-François Lavallée، نويسنده ,
Abstract :
Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.
