Author/Authors :
Neil R. Curtis، نويسنده , , Janusz J. Kulagowski، نويسنده , , Paul D. Leeson، نويسنده , , Ian M. Mawer، نويسنده , , Mark P. Ridgill، نويسنده , , Michael Rowley، نويسنده , , Sarah Grimwood، نويسنده , , George R. Marshall، نويسنده ,
Abstract :
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety.
