Author/Authors :
Aurash Shahripour، نويسنده , , Mark S. Plummer، نويسنده , , Elizabeth A. Lunney، نويسنده , , Kimberly S. Para، نويسنده , , Charles J. Stankovic، نويسنده , , John R. Rubin، نويسنده , , Christine Humblet، نويسنده , , James H. Fergus، نويسنده , , James S. Marks MD MPH، نويسنده , , Roman Herrera، نويسنده , , Susan E. Hubbell، نويسنده , , Alan R. Saltiel، نويسنده , , Tomi K. Sawyer، نويسنده ,
Abstract :
We have designed and synthesized a series of phosphorylated penta- and tri-peptides of general structures Rx-Glu-Glu-Ile-Glu and Rx-Glu- -Trp-NH2, where Rx represents a phosphotyrosine mimetic. These peptides show binding affinity to pp60src SH2 domain in the micromolar range. Data are presented that provide an account of their structure-activity relationships and specificity properties.
We have designed and synthesized a series of phosphorylated penta- and tri-peptides of general structures Rx-Glu-Glu-Ile-Glu and Rx-Glu- -Trp-NH2, where Rx represents a phosphotyrosine mimetic. These peptides show binding affinity to pp60arc SH2 domain in the micromolar range. Data are presented that provide an account of their structure-activity relationships and specificity properties.
