Author/Authors :
Samuel Chackalamannil، نويسنده , , Chia-Shin Chung، نويسنده , , Andrew W. Stamford، نويسنده , , Brian A. McKittrick، نويسنده , , Yuguang Wang، نويسنده , , Hsingan Tsai، نويسنده , , Reneé Cleven، نويسنده , , Ahmad Fawzi، نويسنده , , Michael Czarniecki، نويسنده ,
Abstract :
Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin converting enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP).
