Author/Authors :
Ravi P. Nargund، نويسنده , , Khaled H. Barakat، نويسنده , , Kang Cheng، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget R. Butler، نويسنده , , Roy G. Smith، نويسنده , , Arthur A. Patchett، نويسنده ,
Abstract :
The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N-terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC50 = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.
