Title of article
Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461
Author/Authors
Syndeep Dugar، نويسنده , , Nathan Yumibe، نويسنده , , John W. Clader، نويسنده , , Monica Vizziano، نويسنده , , Keith Huie، نويسنده , , Margaret Van Heek، نويسنده , , Douglas S. Compton، نويسنده , , Harry R. Davis Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1271
To page
1274
Abstract
Based on the metabolism of the potent cholesterol absorption inhibitor (−) SCH48461 and structure activity relationship information, we designed and evaluated (−)SCH 53079. This compound was found to be equipotent to (−)SCH 48461 in both the cholesterol-fed hamster and rhesus monkey assays. Importantly, (−)SCH 53079 was metabolically more stable than (−)SCH 48461 and as desired had very low plasma levels and did not cause hepatic enzyme induction.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788101
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