Author/Authors :
Syndeep Dugar، نويسنده , , Nathan Yumibe، نويسنده , , John W. Clader، نويسنده , , Monica Vizziano، نويسنده , , Keith Huie، نويسنده , , Margaret Van Heek، نويسنده , , Douglas S. Compton، نويسنده , , Harry R. Davis Jr.، نويسنده ,
Abstract :
Based on the metabolism of the potent cholesterol absorption inhibitor (−) SCH48461 and structure activity relationship information, we designed and evaluated (−)SCH 53079. This compound was found to be equipotent to (−)SCH 48461 in both the cholesterol-fed hamster and rhesus monkey assays. Importantly, (−)SCH 53079 was metabolically more stable than (−)SCH 48461 and as desired had very low plasma levels and did not cause hepatic enzyme induction.
