Author/Authors :
Stefano Manfredini، نويسنده , , Rita Bazzanini، نويسنده , , Pier Giovanni Baraldi، نويسنده , , Daniele Simoni، نويسنده , , Silvia Vertuani، نويسنده , , Alessandra Pani، نويسنده , , Elisabetta Pinna، نويسنده , , Franca Scintu، نويسنده , , Donatella Lichino، نويسنده , , Paolo La Colla، نويسنده ,
Abstract :
In a SAR study on azole-related nucleosides we have designed some pyrazole-nucleoside analogs characterised, for the first time, by a carboxylic ester moiety. 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate showed a wide spectrum of antiproliferative activity and a particularly low cytotoxicity against resting PBL, being, unlike the other azole nucleosides, more active than the corresponding primary amide.
