Author/Authors :
M. Lamothe، نويسنده , , D. Perrin، نويسنده , , D. Blotières، نويسنده , , M. Leborgne، نويسنده , , S. Gras، نويسنده , , D. Bonnet، نويسنده , , B. T. Hill، نويسنده , , S. Halazy ، نويسنده ,
Abstract :
New farnesyl phosphonate derivatives of phenylalanine have been prepared as inhibitors of farnesyl-protein transferase (FPT). Enzyme inhibition studies with bovine brain FPT and rat liver squalene synthase show that compound is a new, potent and selective FPT inhibitor. Moreover, structural modifications from have provided some useful information concerning the key structural subunits necessary for optimum and selective FPT inhibition.
