Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue

(Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.