Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors
Author/Authors :
John Lloyd، نويسنده , , Joan B. Schmidt، نويسنده , , John T. Hunt، نويسنده , , Joel C. Barrish، نويسنده , , Deborah K. Little، نويسنده , , Adrienne A. Tymiak، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
4
From page :
1323
To page :
1326
Abstract :
We have synthesized a series of phosphinic acids by solid phase peptide synthesis where we have explored effect on inhibition of changes in the P2′ binding site. The most potent compounds show inhibition of ECE similar to phosphoramidon.
