Author/Authors :
Satoshi Obika، نويسنده , , Yoshihiro Takashima، نويسنده , , Yasuhide Matsumoto، نويسنده , , Atsuko Shimoyama، نويسنده , , Yasuo Koishihara، نويسنده , , Yoshiyuki Ohsugi، نويسنده , , Takefumi Doi، نويسنده , , Takeshi Imanishi، نويسنده ,
Abstract :
Novel heterodimers containing an acyclic nucleoside and a carbamate linkage were incorporated into oligonucleotides, and the melting temperatures of the DNA-DNA and DNA-RNA duplexes as well as the nuclease resistance of the modified oligonucleotides were studied.