Title of article
Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors
Author/Authors
Qi Han، نويسنده , , Jennifer Lafontaine، نويسنده , , Lee T. Bacheler، نويسنده , , Marlene M. Rayner، نويسنده , , Ronald M. Klabe، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Patrick Y. S. Lam، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1371
To page
1374
Abstract
Several bis-N-alkylated (+)-biotin derivatives were synthesized and evaluated for activities against HIV-1 protease. The most potent inhibitor, 2D, synthesized in two steps from (+)-biotin, has Ki of 0.50 μM and antiviral IC90 of 7 μM. The (+)-biotin analogs in general have good translations from enzymatic Ki to antiviral cell assay IC90.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788121
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