Title of article
Adenosine dialdehyde analogs I: Regioselective synthesis of adenosine monoaldehydes
Author/Authors
John P. Neenan، نويسنده , , Sumittada M. Opitz، نويسنده , , Charles L. Cooke، نويسنده , , Michael A. Ussery، نويسنده , , Terence C. Morrill، نويسنده , , Linda M. Eckel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1381
To page
1386
Abstract
Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2′-monoaldehyde (2). Reaction of 1 with N,N′-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3′-monoaldehyde (5), a new compound. Unlike 2, compound 5 inhibited S-AdoHcy hydrolase and showed antiviral activity in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788123
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