Title of article
Improved synthesis of oligonucleoside methylphosphonate analogs
Author/Authors
Ivan Habus، نويسنده , , Theresa Devlin، نويسنده , , Radhakrishnan P. Iyer، نويسنده , , Sudhir Agrwal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1393
To page
1398
Abstract
Solid-phase synthesis using pent-4-enoyl nucleoside PNT phosphonamidites allow for the facile preparation of oligonucleoside methylphosphonates, methylphosphonothioates and their chimeric analogs. With PNT phosphonamidites, nucleobase and phosphate deprotection, as well as, cleavage from the support can all be accomplished by treatment of the support-bound oligonucleotide with NH4OH (28%, rt, 1 h).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788125
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