Title of article :
Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists
Author/Authors :
Yasuyuki Kawanishi، نويسنده , , Shoichi Ishihara، نويسنده , , Tadahiko Tsushima، نويسنده , , Kaoru Seno، نويسنده , , Masanori Miyagoshi، نويسنده , , Sanji Hagishita، نويسنده , , Michio Ishikawa، نويسنده , , Noriko Shima، نويسنده , , Mayumi Shimamura، نويسنده , , Yasunobu Ishihara، نويسنده ,
Abstract :
The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding sites of both pharmacophores for the dual activity.
