Title of article
Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists
Author/Authors
Yasuyuki Kawanishi، نويسنده , , Shoichi Ishihara، نويسنده , , Tadahiko Tsushima، نويسنده , , Kaoru Seno، نويسنده , , Masanori Miyagoshi، نويسنده , , Sanji Hagishita، نويسنده , , Michio Ishikawa، نويسنده , , Noriko Shima، نويسنده , , Mayumi Shimamura، نويسنده , , Yasunobu Ishihara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1421
To page
1426
Abstract
The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding sites of both pharmacophores for the dual activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788130
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