Title of article :
Design, synthesis, and evaluation of fibrinogen inhibitors, ω-(p-amidinophenoxy) alkanoylaspartic acid derivatives
Author/Authors :
Akito Tanaka، نويسنده , , Hiroyoshi Sakai، نويسنده , , Takatoshi Ishikawa، نويسنده , , Isao Nakanishi، نويسنده , , Mitsuru Ohkubo، نويسنده , , Toshiaki Aoki، نويسنده , , Yukio Motoyama، نويسنده , , Hisashi Takasugi، نويسنده ,
Abstract :
Low molecular weight inhibitors of platelet aggregation are described. Compounds studied in this work were derived from the presumed active conformation of the adhesion tripeptide, ArgGlyAsp, using computer simulations. These studies led to the synthesis of a potent anti-platelet agent, 4-(4-amidinophenoxy)-butanoylaspartylvaline (6, FK633).
