Design, synthesis, and evaluation of fibrinogen inhibitors, ω-(p-amidinophenoxy) alkanoylaspartic acid derivatives

Low molecular weight inhibitors of platelet aggregation are described. Compounds studied in this work were derived from the presumed active conformation of the adhesion tripeptide, ArgGlyAsp, using computer simulations. These studies led to the synthesis of a potent anti-platelet agent, 4-(4-amidinophenoxy)-butanoylaspartylvaline (6, FK633).