Title of article
Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity
Author/Authors
N. Hossain، نويسنده , , C. Hendrix، نويسنده , , E. Lescrinier، نويسنده , , A. Van Aerschot، نويسنده , , R. Busson، نويسنده , , E. De Clercq، نويسنده , , P. Herdewijn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1465
To page
1468
Abstract
Homo-N-nucleosides can be efficiently synthesized from 2-deoxyribose. When incorporated in an oligonucleotide, the compounds have a detrimental influence on duplex stability and on the catalytic activity of hammerhead ribozymes. However, homo-N-nucleosides with a guanine or adenine base moiety do exhibit selective antiviral activity against herpes simplex virus (HSV-1 and HSV-2).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788139
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