Author/Authors :
Hideyuki Kanno، نويسنده , , Ken Osanai، نويسنده , , Tatsuya Nishi، نويسنده , , Minoru Iino، نويسنده , , Shin-ichi Katakura، نويسنده , , Taketoshi Furugohri، نويسنده , , Yoshifumi Watanabe، نويسنده ,
Abstract :
A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2ʹ position, was evaluated by a computer analysis.
