Title of article
Substituted morpholine-2S-acetic acid derivatives: Sch 50911 and related compounds as novel GABAB antagonists
Author/Authors
David J. Blythin، نويسنده , , Shen-Chun Kuo، نويسنده , , Ho-Jane Shue، نويسنده , , Andrew T. McPhail، نويسنده , , Richard W. Chapman، نويسنده , , William Kreutner، نويسنده , , Charles Rizzo، نويسنده , , Hoyan S. She، نويسنده , , Robert West، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1529
To page
1534
Abstract
The synthesis and GABAB antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X-ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788153
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