Title of article
Neuroprotective (+) 3S, 4S cannabinoids with modified 5′-side chain
Author/Authors
Emil Pop، نويسنده , , Clinton E. Browne، نويسنده , , Varda Nadler، نويسنده , , Anat Biegon، نويسنده , , Marcus E. Brewster، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1553
To page
1558
Abstract
The synthesis and evaluation of two novel cannabinoids belonging to the (+) 3S, 4S nonpsychotropic series are described. These derivatives bind to the NMDA receptor but have lower affinities than dexanabinol (HU-211), the series benchmark. The novel compounds protect neurons against NMDA-induced toxicity in cortical cell cultures and have lower toxicity to host neurons than dexanabinol.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788158
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