Title of article
Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors
Author/Authors
Vittorio Rasetti، نويسنده , , N. Claude Cohen، نويسنده , , Heinrich Rüeger، نويسنده , , Richard G?schke، نويسنده , , Jürgen Maibaum، نويسنده , , Frederic Cumin، نويسنده , , Walter Fuhrer، نويسنده , , Jeanette M. Wood، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1589
To page
1594
Abstract
The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, lowmolecular weight renin inhibitors with improved pharmacokinetic properties.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788166
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