SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

Novel 2-benzyl-4-aminopiperidines have been shown to be potent and selective antagonists at the NK1 receptor. Some compounds of this series, e.g. CGP 49823 (2), show CNS activity after oral administration.