Title of article
Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®
Author/Authors
Dominique Damour، نويسنده , , Michel Barreau، نويسنده , , Jean-Charles Blanchard، نويسنده , , Marie-Claude Burgevin، نويسنده , , Adam Doble، نويسنده , , Frederic Herman، نويسنده , , Guy Pantel، نويسنده , , Evelyne James-Surcouf، نويسنده , , Marc Vuilhorgne، نويسنده , , Serge Mignani، نويسنده , , Lydie Poitout، نويسنده , , Yves Le Merrer، نويسنده , , Jean-Claude Depezay، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1667
To page
1672
Abstract
Based on molecular modelling studies of Sandostatin®, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin®. These compounds displaced 3-[125I]-Tyr11-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC50 values between 10 and 15 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788180
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