Title of article
Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the N-carboxyalkylamine and glutaramide carboxylate series
Author/Authors
Ralph P. Robinson، نويسنده , , Brian J. Cronin، نويسنده , , Kathleen M. Donahue، نويسنده , , Brian P. Jones، نويسنده , , Lori L. Lopresti-Morrow، نويسنده , , Peter G. Mitchell، نويسنده , , James P. Rizzi، نويسنده , , Lisa M. Reeves، نويسنده , , Sue A، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1725
To page
1730
Abstract
Modification of the N-carboxyalkylamine 3 by independent replacement of the P1′ NH group for CH2 and introduction of P1′ gem-cyclohexyl substitution affords compounds 5 and 6a which retain appreciable activity against MMP-1 (IC50s = 0.023 μM and 0.09 μM, respectively). The glutaramide 7a which incorporates both these structural changes also retains potent activity (IC50 = 0.038 μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788191
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