Author/Authors :
Ralph P. Robinson، نويسنده , , Brian J. Cronin، نويسنده , , Kathleen M. Donahue، نويسنده , , Brian P. Jones، نويسنده , , Lori L. Lopresti-Morrow، نويسنده , , Peter G. Mitchell، نويسنده , , James P. Rizzi، نويسنده , , Lisa M. Reeves، نويسنده , , Sue A، نويسنده ,
Abstract :
Modification of the N-carboxyalkylamine 3 by independent replacement of the P1′ NH group for CH2 and introduction of P1′ gem-cyclohexyl substitution affords compounds 5 and 6a which retain appreciable activity against MMP-1 (IC50s = 0.023 μM and 0.09 μM, respectively). The glutaramide 7a which incorporates both these structural changes also retains potent activity (IC50 = 0.038 μM).
