Title of article
Peptidomimetic growth hormone secretagogues: synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752
Author/Authors
Ravi P. Nargund، نويسنده , , Meng-Hsin Chen، نويسنده , , David B. R. Johnston، نويسنده , , Khaled J. Barakat، نويسنده , , James R. Tata، نويسنده , , Kang Cheng، نويسنده , , Thomas M. Jacks، نويسنده , , Wanda W. -S. Chan، نويسنده , , Liente Wei، نويسنده , , Bridget R. Butler، نويسنده , , Gerard J. Hickey، نويسنده , , Roy G. Smith، نويسنده , , Arthur A. Patchett، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1731
To page
1736
Abstract
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with significantly better oral activity in dogs. Use of dimethyl β-alanine amino side-chains led to a considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788192
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