Title of article
Tc-99m-labeled fibrinogen receptor antagonists: design and synthesis of cyclic RGD peptides for the detection of thrombi
Author/Authors
Thomas D. Harris، نويسنده , , Milind Rajopadhye، نويسنده , , Paul R. Damphousse، نويسنده , , Danuta Glowacka، نويسنده , , Karmine Yu، نويسنده , , Jeffrey P. Bourque، نويسنده , , John A. Barrett، نويسنده , , David J. Damphousse، نويسنده , , Stuart J. Heminway، نويسنده , , Joel Lazewatsky، نويسنده , , Theresa Mazaika، نويسنده , , Timothy R. Carroll، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1741
To page
1746
Abstract
Tc-99m labeled derivatives of N-Me-Arg-Gly-Asp containing cyclic peptide GP IIb/IIIa receptor antagonists are potential radiopharmaceuticals for the diagnosis of thrombosis. The design and synthesis of these peptides are described. These compounds are incorporated in rapidly growing thrombi under both arterial and venous conditions in canine models. Thrombi are clearly visible in images acquired at 50 min.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788194
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