Title of article
Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs
Author/Authors
Jerzy Golik، نويسنده , , Henry S. L. Wong، نويسنده , , Shu-Hui Chen، نويسنده , , Terrence W. Doyle، نويسنده , , J. J. Kim Wright، نويسنده , , Jay Knipe، نويسنده , , William C. Rose، نويسنده , , Anna Maria Casazza، نويسنده , , Dolatrai. M. Vyas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1837
To page
1842
Abstract
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8–11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The antitumor evaluation of compounds 8–11 established them as suitable pro-drugs of paclitaxel.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788212
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