Author/Authors :
Jerzy Golik، نويسنده , , Henry S. L. Wong، نويسنده , , Shu-Hui Chen، نويسنده , , Terrence W. Doyle، نويسنده , , J. J. Kim Wright، نويسنده , , Jay Knipe، نويسنده , , William C. Rose، نويسنده , , Anna Maria Casazza، نويسنده , , Dolatrai. M. Vyas، نويسنده ,
Abstract :
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8–11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The antitumor evaluation of compounds 8–11 established them as suitable pro-drugs of paclitaxel.
