Title of article
Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistry
Author/Authors
Michael A. Foley، نويسنده , , Angela S. Hassman، نويسنده , , David H. Drewry، نويسنده , , David G. Greer، نويسنده , , Craig D. Wagner، نويسنده , , Paul L. Feldman، نويسنده , , Judd Berman، نويسنده , , D. Mark Bickett، نويسنده , , Gerry M. McGeehan، نويسنده , , Millard H. Lambert and H. Eric Xu، نويسنده , , Michael Green، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1905
To page
1910
Abstract
Solid phase chemistry expedited the systematic modification of the C and N-terminal groups of cysteine derived lead compound 1 (collagenase IC50 63nM), providing a series of matrix metalloproteinase inhibitors. Potent inhibitors of collagenase (1–2, 4–6, and 10–13) and gelatinase (4–8) were identified. Insights into the binding mode of selective inhibitors will be discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788225
Link To Document