Thiono triester modified antisense oligonucleotides for inhibition of human cytomegalovirus in vitro
Author/Authors :
Zhaoda Zhang، نويسنده , , Jean A. Smith، نويسنده , , Adrienne P. Smyth، نويسنده , , Warren Eisenberg، نويسنده , , Gregory S. Pari، نويسنده , , Jin Yan Tang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
6
From page :
1911
To page :
1916
Abstract :
A series of thiono triester containing oligonucleotide phosphorothioates linked with a lipophilic group have been successfully synthesized. Some of these modified antisense oligonucleotides show potent anti-HCMV activity as well as improved cellular association and nuclease resistance.
