Title of article
Synthesis of azido derivatives of semotiadil, a novel 1,4-benzothiazine calcium antagonist, for photoaffinity probes of calcium channels
Author/Authors
Yoshifumi Watanabe، نويسنده , , Ken Osanai، نويسنده , , Tatsuya Nishi، نويسنده , , Nobuaki Miyawaki، نويسنده , , Daisuke Shii، نويسنده , , Toshio Honda، نويسنده , , Toshiro Shibano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1923
To page
1926
Abstract
Aliphatic and aromatic azido derivatives of semotiadil (1), a novel calcium antagonist with a 1,4-benzothiazine skeleton, were synthesized for developing photoaffinity probes of L type calcium channels. The azidophenoxy derivative 12proved to be a potent calcium antagonist and its [3H]-labeled compound 16 would be a useful tool to clarify the binding sites of 1 to the calcium channels.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788228
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