Title of article
Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine A
Author/Authors
Satoru Kaneko، نويسنده , , Noriyuki Nakajima، نويسنده , , Mayumi Shikano، نويسنده , , Ta-i Katoh، نويسنده , , Shiro Terashima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1927
To page
1930
Abstract
Three novel fouorinated analogues of huperzine A (1), (±)-12,12,12-trifluorohuperzine A (2), (±)-14,14,14-trifluorohuperzine A (3), and (±)-12,12,12,14,14,14-hexafluorohuperzine A (4), have been synthesized by employing TMSCF3 as a trifluoromethylating agent. These analogues were found to still retain anti-acetylcholinesterase activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788229
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