Title of article
Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®
Author/Authors
Craig A. Coburn، نويسنده , , Mary Beth Young، نويسنده , , Randall W. Hungate، نويسنده , , Richard C. A. Isaacs، نويسنده , , Joseph P. Vacca، نويسنده , , Joel R. Huff، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1937
To page
1940
Abstract
A series of analogs of CRIXIVAN® containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788231
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