Author/Authors :
Craig A. Coburn، نويسنده , , Mary Beth Young، نويسنده , , Randall W. Hungate، نويسنده , , Richard C. A. Isaacs، نويسنده , , Joseph P. Vacca، نويسنده , , Joel R. Huff، نويسنده ,
Abstract :
A series of analogs of CRIXIVAN® containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.
