Title of article
Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activity
Author/Authors
A. Hüls، نويسنده , , K. Purand، نويسنده , , B. H. Stark، نويسنده , , X. Ligneau، نويسنده , , J. -M. Arrang، نويسنده , , J. -C. Schwartz، نويسنده , , W. Schunack، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2013
To page
2018
Abstract
New potent histamine H3-receptor antagonists containing an ether group were synthesized from 3-(1H-imidazole-4-yl)propanol and various substituted diphenylmethyl chlorides. Some of the designed ethers showed high activity at histamine H3-receptors under in vitro as well as under in vivo conditions. Their activity at histamine H1- and H2-receptors was also investigated proving a pharmacological H3-/H1-antagonistic profile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788246
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