Title of article
Synthesis and biological evaluation of 4-alkoxysubstituted trinems. Part II
Author/Authors
Romano Di Fabio، نويسنده , , Daniele Andreotti، نويسنده , , Stefano Biondi، نويسنده , , Giovanni Gaviraghi، نويسنده , , Tino Rossi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2025
To page
2030
Abstract
The synthesis and the microbiological evaluation of a novel series of substituted tricyclic β-lactam derivatives (trinems, former named tribactams) is reported. Suitable basic groups were introduced within the key C-4 side chain with the aim of improving the antibacterial activity of this class of new antibiotics to Pseudomonas spp.. Among the different compounds prepared, basic derivatives 2 and 3 showed improved activity with respect to GV 104326 1 against these highly resistant strains.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788248
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