Synthesis of all possible regioisomers of myo-Inositol pentakisphosphate

Synthesis of all possible 4 regioisomers of IP5, naturally occurring metabolites of IP3 and IP4, was accomplished from myo-inositol via its monobenzoate derivatives (IBz1) as the key intermediates; base-catalyzed isomerization of readily available IBz1 derivatives, followed by suitable separation procedures efficiently provided the requisite regioisomers of IBz1.