Title of article
Stereoselective synthesis of lewis-associated trisaccharides as E-selectin inhibitors
Author/Authors
Naonori Imazaki، نويسنده , , Haruhiko Koike، نويسنده , , Hiroshi Miyauchi، نويسنده , , Masaji Hayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2043
To page
2048
Abstract
Three types of Lewis-associated trisaccharides [the Lea analogs, their epimers with respect to the fucose residue (the 1 c-epi-Lea analogs), and the Lex analogs] were synthesized in a stereoselective manner. Not only the Lea analogs but also the 1 c-epi-Lea analogs inhibited E-selectin-mediated neutrophil accumulation into pleural cavity in lipoteichoic acid-treated mice, with the trend being Lea> 1 c-epi-Lea> Lex.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788251
Link To Document