Author/Authors :
Atsushi Akahane، نويسنده , , Hirohito Katayama، نويسنده , , Takafumi Mitsunaga، نويسنده , , Yasuhiro Kita، نويسنده , , Takahiro Kusunoki، نويسنده , , Takao Terai، نويسنده , , Keizo Yoshida، نويسنده , , Youichi Shiokawa، نويسنده ,
Abstract :
Novel 2-phenylpyrazolo[1,5-a]pyridine-3-acryloylamides were synthesized and evaluated for diuretic activities. FK453 (1d), the most potent compound in this series, was found to be a potent and selective adenosine A1 receptor antagonist, whereas 1e, the (S)-enantiomer of FK453, was a weak and non-selective adenosine antagonist.
