Title of article
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist
Author/Authors
Atsushi Akahane، نويسنده , , Hirohito Katayama، نويسنده , , Takafumi Mitsunaga، نويسنده , , Yasuhiro Kita، نويسنده , , Takahiro Kusunoki، نويسنده , , Takao Terai، نويسنده , , Keizo Yoshida، نويسنده , , Youichi Shiokawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2059
To page
2062
Abstract
Novel 2-phenylpyrazolo[1,5-a]pyridine-3-acryloylamides were synthesized and evaluated for diuretic activities. FK453 (1d), the most potent compound in this series, was found to be a potent and selective adenosine A1 receptor antagonist, whereas 1e, the (S)-enantiomer of FK453, was a weak and non-selective adenosine antagonist.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788254
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