Title of article
Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog
Author/Authors
Isidoros Vlattas، نويسنده , , James Dellureficio، نويسنده , , Edmund Ku، نويسنده , , Regine Bohacek، نويسنده , , Xiaolu Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2091
To page
2096
Abstract
Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that are potent inhibitors of the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788262
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