Title of article
Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring
Author/Authors
Cherie Taylor، نويسنده , , Ronald J. Quinn، نويسنده , , Masami Suganuma، نويسنده , , Hirota Fujiki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2113
To page
2116
Abstract
Several synthetic analogues of microcystin-LR and nodularin at 1 mM inhibited PP2A. The active microcystin analogues were cyclic heptapeptides envisaged to interact with the catalytic subunit of PP1 and PP2A when an Adda-type hydrophobic group was added. The cyclic core was found to have some intrinsic phosphatase inhibitory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788266
Link To Document