Title of article
Studies on the active metabolite (DU-86) of KW-2189, a novel derivative of duocarmycin
Author/Authors
Satoru Nagamura، نويسنده , , Eiji Kobayashi، نويسنده , , Katsushige Gomi، نويسنده , , Hiromitsu Saito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2147
To page
2150
Abstract
Some derivatives of DU-86 as an active metabolite of KW-2189, which is a novel duocarmycin derivative, have been synthesized and evaluated for the biological activity. The results suggested that the methylation of aromatic NH moiety showed extremely decreased anticellular and antitumor activity, demonstrating that the free NH moiety play an important role in the biological activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788313
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