Author/Authors :
Meng-Hsin Chen، نويسنده , , Mark G. Steiner، نويسنده , , Arthur A. Patchett، نويسنده , , Kang Cheng، نويسنده , , Liente Wei، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget Butler، نويسنده , , Thomas M. Jacks، نويسنده , , Roy G. Smith، نويسنده ,
Abstract :
A series of spiroindane growth hormone secretagogues that vary in their amino side chains is reported. Variations in these side chains markedly affect growth hormone release in vitro and in vivo. The best side chain in this series of secretagogues is α-methylalanine. L-162,752 not only stimulated GH release from rat pituitary cells, but also induced GH release in dogs upon i.v. and p.o. administration.
