Title of article
Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin
Author/Authors
Peter J. Sinclair، نويسنده , , Frederick Wong، نويسنده , , Mary Jo Staruch، نويسنده , , Greg Wiederrecht، نويسنده , , William H. Parsons، نويسنده , , Francis Dumont، نويسنده , , Mathew Wyvratt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2193
To page
2196
Abstract
The synthesis of naphthyl- and indolyl-ethers of the immunosuppressive macrolide ascomycin using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported. The indole ether analogs show increased immunosuppressive activity in vitro relative to the parent macrolide.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788322
Link To Document